- Year: 2015
- Page Number: 345
- File Type: PDF
- File Size: 7.06 MB
- Authors/ Editiors: Firth, Amy
This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed.
World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.
Amy Firth, Ph.D. received both her M.Sc. in Pharmacology and her Ph.D. in Pulmonary Physiology and Ion Channel Regulation at University of Bath, UK. For two years, she was a Postdoctoral Fellow at UC San Diego where she studied the pathogenic mechanisms contributing to Pulmonary Hypertension. For this work she was a finalist in the American Heart Association’s Cournand and Comroe Young Investigator Award. She is currently a Research Associate at The Salk Institute where her research focuses on generating iPSCs from somatic cells of patients with various diseases, primarily respiratory. By differentiating these cells she is able to study the pathogenic mechanisms of a variety of lung diseases. She is a member of several international societies including International Society for Stem Cell Research (ISSCR), the American Physiological Society and the American Thoracic Society.
“The purpose is to present the latest information and address new research directions and potential clinical applications in the field of lung stem cell biology. The audience includes scientists working in industry and academia, physicians and other healthcare professionals, and students of biomedical sciences interested in the field of lung stem cell biology and regenerative medicine. … This is a good overview of the directions and challenges in this quickly evolving field.” (Joanna Goral, Doody’s Book Reviews, January 2016)
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