Diffuse Lung Disease A Practical Approach 2nd Edition (2011) (PDF) by Robert P. Baughman

Description

Interstitial lung diseases comprise a significant part of any respiratory medicine practice. This timely second edition of Diffuse Lung Disease is a practical clinically-oriented resource, covering all the major advances in diagnostic techniques and therapies. Authored by world authorities in the field, this book provides clear and specific recommendations for the management of all forms of interstitial lung diseases.

This book is divided into two sections. The first section addresses the general aspects of diagnosis and management, including clinical approach, radiographic approach, physiological changes, and classification. The second section details each individual form of interstitial lung disease. Organized in an easy to follow format, each disease specific chapter includes tables outlining diagnostic approach, differential diagnosis, disease monitoring, and treatment. Illustrative cases, replete with high quality HRCT images, bring an added dimension to this outstanding book.

User’s Reviews

The lung is exceptional in that pathologic changes can be seen clearly in radiographs because of the air-tissue contrast. When bilateral diffuse, ill-defined shadows are seen, one begins to speculate on the cause — infection, inflammation, or neoplasm? This process is one of the most exciting by which chest physicians approach a diagnosis. As a practical guide, Diffuse Lung Disease provides current and approved approaches to diffuse lung diseases caused by complex inflammatory mechanisms. The book has two parts — one on general considerations and one on specific diseases, which includes 11 case presentations. During the creation of a consensus statement on idiopathic pulmonary fibrosis in the late 1990s, the notion was established that the diagnosis of diffuse lung diseases should be collectively interpreted according to the clinical findings (crucial in the recording of patient history), radiologic results (obtained with the use of high-resolution computed tomography [CT]), and pathological findings (from biopsy specimens obtained during thoracoscopic surgery). Consistent with this notion, the book offers plenty of typical high-resolution CT scans and beautiful photomicrographs of pulmonary-biopsy specimens. In contrast to these diagnostic procedures, the reader may find that the therapeutic approaches to diffuse lung diseases are limited. Conventional immunosuppressive agents are the principal treatments for pulmonary fibrosis, granulomas, or vasculitis, although the effects are not always satisfactory. However, macrolides have been found to be effective in chronic bronchiolitis, and rapamycin may target lymphangioleiomyomatosis. New monoclonal antibodies are promising agents for future clinical trials. The implications with regard to the causes of diffuse lung diseases are surprisingly broad. For example, the common use of down clothing or bedding should be considered as a possible cause of hypersensitivity pneumonitis and the use of supplements such as vitamins as a possible cause of organizing pneumonia. Although it is not covered in this book, a recent example is the relatively high mortality associated with interstitial lung disease in patients taking gefitinib, a drug used in the treatment of non-small-cell lung cancer. For a better understanding of diffuse lung diseases, a clarification of the causes, in molecular terms, is needed. One example in this book involves pulmonary alveolar proteinosis. An autoantibody against granulocyte-macrophage colony-stimulating factor has been implicated in the causation of idiopathic pulmonary alveolar proteinosis, and treatment for B-cell diseases thus could be considered for this condition. For the global search for genes related to diffuse lung diseases, precise family histories are indispensable. For this purpose, high-resolution CT scanning in asymptomatic siblings of patients with diffuse or destructive lung diseases could provide crucial information. This book concisely summarizes our current understanding of diffuse lung diseases and will be a valuable guide to physicians in the examination of bilateral diffuse pulmonary shadows in chest radiographs. Toshihiro Nukiwa, M.D., Ph.D.

Excellent book for pneumonologists who want to buy a book for interstitial lung diseases. It covers all the aspects of diffuse lung disease. A book that every respiratory physician should have in his library

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