Ebook Info
- Published: 2017
- Number of pages:
- Format: PDF
- File Size: 11.78 MB
- Authors: Rudy J Richardson
Description
This book presents systems pharmacology and toxicology approaches to computational toxicology, linking chemical exposures to genes, diseases and complex biological pathways. It discusses new methods to study chemical and biological target elucidation and computational models. These computational tools hold tremendous promise for advancing applied and basic science, streamlining drug efficacy and safety testing, reducing the use of animals in testing, and increasing the efficiency and effectiveness of risk assessment for environmental chemicals. This timely and modern book will be of interest to risk assessors as well as toxicologists and pharmacologists. The case study section will make it particularly useful for academic course work at graduate and undergraduate level.
Reviews
This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics.
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