Ebook Info
- Published:
- Number of pages:
- Format: PDF
- File Size: 11.89 MB
- Authors: Marc Sindou
Description
This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.
Reviews
Niruj Agrawal, Consultant Neuropsychiatrist, St George’s Hospital, London, United Kingdom, Rafey Faruqui, Consultant Neuropsychiatrist, Kent and Medway NHS and Social Care Partnership Trust, United Kingdom, Mayur Bodani, Consultant, Kent and Medway NHS and Social Care Partnership Trust, Departmentof Neuropsychiatry, Gillingham, United KingdomDr Niruj Agrawal is a consultant neuropsychiatrist at St George’s Hospital. He trained at St George’s Hospital, Charing Cross, and the National Hospital for Neurology and Neurosurgery. Dr Agrawal also consults at the Wolfson Neurorehabilitation Centre.Professor Rafey Faruqui is former Chair of Neuropsychiatry Faculty at the Royal College of Psychiatrists, London. He is a consultant neuropsychiatrist at the East Kent Neuropsychiatry Service and leads Kent Brain Health and Neuroplasticity Research Group . He is an Honorary Professor in the Centreof Health Services Studies at the University of Kent where he has completed a five year mapping of Head Injury Pathway in Kent working with Kent Public Health Observatory. He has previously served as Specialist Adviser to Care Quality Commission, UK and as a member of Mental Health SpecializedClinical Reference Group of NHS England.Dr Mayur Bodani is a consultant neuropsychiatrist with Kent and Medway NHS and Social Care Partnership Trust. His primary research interests are non-invasive neuro-technologies as adjuncts in the management of chronic symptoms of long-term motor conditions, and the design and application of devicesfor the management of neuropsychiatric conditions.
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