G Protein Signaling Mechanisms in the Retina (Springer Series in Vision Research, 3) 2014th Edition (2014) by Kirill A. Martemyanov PDF

Description

The main purpose of this volume is to provide a focused analysis of the function of the G protein-coupled signaling pathways that operate in the interconnected network of retinal neurons as they detect and encode the information carried by light. The organization of this volume will generally follow the path of signal flow in the retina. First we will describe recent advances in understanding the phototransduction cascade of rod and cone photoreceptors, which use signaling cascade based on the GPCR rhodopsin to transduce incident light into neural activity. Chapters will be devoted to unique specializations of the two major types of photosensitive cells that comprise the predominant input for our spatial and color vision. Subsequently, the mechanisms of synaptic information encoding by retinal ON bipolar cells will be described, where the GPCR mGluR6 plays a fundamental role. Chapters in this section will examine macromolecular organization of the mGluR6 signaling pathway as well as current understanding of its function. The functional characteristics of this signaling mechanism will be explored in detail. Additionally, this section will cover the role of dopamine receptors in modulating signal transmission between photoreceptors and ON-bipolar cells. Finally, chapters will be focused on the output neurons of the inner retina, ganglion cells, where the components of the emerging GPCR melanopsin cascade in intrinsically photosensitive ganglion cells will be detailed. Collectively these mechanisms allow the retina to represent visual space over a wide range of light intensities.

Reviews

Reviews from Amazon users which were colected at the time this book was published on the website:

⭐G Protein Signaling Mechanisms in the RetinaSpringer Verlag New York Berlin HeidelbergRe: Joseph Grenier MD PhDThis is an excellent monograph of Rod and Cone physiology in the retina preparation. G proteins with knockout and transgnenic mice are used to look at the mechanisms of vision through receptors, on RPE, bipolar and ganglionic cells. The kinetics of ionic channels is examine d in detail. This is an important book for ophthalmology researchers, graduate, and biochemistry students.G protein kinases and signal transduction cascades are looked at in great detail, as is the RPE knockouts lacking the ERG waves associated with the wild type mice. The tracings and evidence support the various theories of this book. It is highly recommended book in visual neurophysiology.