Immune Thrombotic Thrombocytopenic Purpura – A Review (2024) Allyson M. Pishko

Description

A review focusing on immune thrombotic thrombocytopenic purpura (iTTP), a life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. It examines the pathogenesis involving ADAMTS13 autoantibodies, clinical presentation, diagnostic prediction scores, and current treatment protocols, including therapeutic plasma exchange, corticosteroids, rituximab, and the use of caplacizumab to reduce recurrence risk. The review also discusses the importance of monitoring ADAMTS13 activity in remission to prevent relapse.