Septic shock – Past, present, and perspectives (2026) Erika P. Plata-Menchaca

Description

This article reviews the evolution of septic shock management, detailing its definition, historical progression from ‘blood poisoning’ to systemic syndrome, and current management strategies including the Surviving Sepsis Campaign. It emphasizes rapid recognition, timely antimicrobials, and vasopressor support, while discussing future directions involving precision medicine, machine learning, and multi-omic approaches to guide individualized treatment.