Quantitative Methods for Precision Medicine – Pharmacogenomics in Action () Unknown Author

Description

This book analyzes the paradigm shift toward patient-customized therapy (Precision Medicine) using powerful computational tools. It presents advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles. It covers functional and systems mapping models, statistical analysis of missing data, functional graph theory for inferring genetic interaction networks, epistasis modeling, and modeling gene-induced cell-cell crosstalk. It is suitable for graduate students and researchers in medicine, biology, bioinformatics, drug design, applied mathematics, and statistics.