p53 in Breast Cancer – Molecular Mechanisms, Clinical Implications, and Therapeutic Targets (2025) Manzoor Ahmad Mir

Description

This book comprehensively reviews the role of p53 in breast cancer development, progression, and treatment. It explores p53’s connection to cancer metabolism, mutational alterations, and its function as a tumor suppressor. The text examines p53’s regulatory roles in cell death, DNA repair, genomic stability, and cell cycle dynamics, highlighting interactions with transcription factors and family members p63 and p73. It also discusses approaches to combat mutated p53, including targeted therapies, and addresses the use of p53 biomarkers in diagnosis and prognosis.