Traumatic Brain Injury – A Comprehensive Review of Biomechanics and Molecular Pathophysiology (2024) Taylor J. Orr

Description

This comprehensive literature review delves into the intricacies of Traumatic Brain Injury (TBI), covering primary injury biomechanics (impact loading, blast overpressure, impulsive loading) and the molecular pathophysiology of the secondary injury cascade. It analyzes molecular and cellular responses, including altered ion concentrations, neurotransmitter dysfunction, oxidative stress, cellular energy disturbances, and neuroinflammatory responses, aiming to bridge the knowledge gap between mechanical forces and molecular consequences for targeted therapeutic development.