The pharmaco‑epigenetics of hypertension – a focus on microRNA (2024) Serge Yaacoub

Description

This critical review examines the role of epigenetics, specifically microRNA (miRNA) molecules, in the etiology and mechanisms of hypertension, a major cardiovascular risk factor. It details how epigenetic alterations (including DNA methylation and histone modification) contribute to the hypertensive molecular phenotype. The article focuses particularly on the experimentally determined associations between miRNAs and hypertension pharmacotherapy, reviewing epigenetic mechanisms underlying physiological responses to antihypertensive drugs like candesartan, as well as relevant drugs like clopidogrel, aspirin, and statins.