Location, location, location – Fibrin, cells, and fibrinolytic factors in thrombi (2023) Anuj Narwal

Description

This mini review discusses the heterogeneous nature of thrombi, where composition and structure are dictated by the site of formation (arterial vs. venous), stimuli, and shear stress. It explores how conventional views on thrombus composition are shifting due to recent medical advances, emphasizing that the distribution of fibrinolytic factors is influenced by cellular makeup, which impacts susceptibility to proteolytic degradation. The text stresses the need for a deeper understanding of thrombus architecture to develop targeted antithrombotic strategies.