Changes in central venous-to-arterial PCO2 difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients – A post-hoc analysis of a multi-center prospective study (2024) Jihad Mallat

Description

This research analyzes whether changes in central venous-to-arterial CO2 difference (ΔP(v–a)CO2) and central venous oxygen saturation (ΔScvO2) induced by volume expansion are reliable parameters to define fluid responsiveness (FR) in sedated and mechanically ventilated septic patients with acute circulatory failure. The study found both ΔP(v–a)CO2 and ΔScvO2 to be reliable parameters for defining FR and usable in the absence of cardiac index measurement.