Antibiotic dose optimisation in the critically ill – Targets, evidence and future strategies (2023) Christopher J. Dyer

Description

This review assesses recent evidence regarding antibiotic dose optimization using pharmacokinetics/pharmacodynamics (PK/PD) and therapeutic drug monitoring (TDM) in critically ill patients with sepsis and septic shock. It emphasizes the need for dose adjustments due to altered pharmacokinetics and summarizes current findings, supporting optimization strategies, while calling for future research into precision dosing technologies to quantify clinical benefits.