Ebook Info
- Published:
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- Format: PDF
- File Size: 20.84 MB
- Authors: Markus D. Schirmer
Description
Dendrimers are highly branched synthetic polymers. It consists of enter core, integral region and numerous functional end groups. The growth of polymer occurs in outward direction from central core by stepwise polymerization. It is characterized with numerous cavities in the core structure creating channels and cages. Precise control of size can be achieved by the extent of polymerization. The intracellular uptake of dendrimers by receptor mediated endocytosis can be aided using the conjugation of biotin (Tomalia et al., 1985). Dendrimers contribute to drug delivery either by binding the drug on the periphery as prodrug, or entrapping the drug in the center core. Recent progress has been made to dendrimer formulary as a biocompatible drug carrier for cancer targeting therapy.
Reviews
This text provides a contemporary review of the diagnosis and surgical management of RCC. It opens with chapters on the pathology, radiology, and genetics of RCC. It then covers the risk stratification of renal tumors utilizing renal mass biopsy as well as non-invasive novel imaging-based scoring systems. Next, the surgical management of small and locally advanced renal tumors as well as the role of surgery in cases of metastatic RCC is reviewed. In addition, alternative approaches to surgery including active surveillance and ablative techniques are reviewed. Other chapters detail the emerging role of neoadjuvant and adjuvant systemic therapy in patients who are at high risk of progression to metastatic disease. Finally, the text covers the post-operative surveillance of patients with RCC as well as a summary of contemporary guidelines on the management of this disease. Diagnosis and Surgical Management of Renal Cell Carcinoma will serve as a comprehensive resource for physicians and researchers interested in RCC. All chapters will be written by experts in the field and will include the most up to date scientific and clinical information. About the Author Michael A. Gorin, M.D.Chief Urology Resident (will hold rank of Assistant Professor at time of publication)Johns Hopkins University School of Medicine600 North Wolfe Street, Marburg 134Baltimore, MD 21287Mohamad E. Allaf, M.D.Associate Professor of Urology, Oncology, and Biomedical EngineeringDirector of Minimally Invasive UrologyJohns Hopkins University School of Medicine600 North Wolfe Street, Park 223Baltimore, MD 21287
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