Role of MicroRNAs in Cancers (2022) by DKV Prasad PDF

 

Ebook Info

  • Published: 2022
  • Number of pages: 192 pages
  • Format: PDF
  • File Size: 2.99 MB
  • Authors: DKV Prasad

Description

This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.

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Editorial Reviews: From the Back Cover This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies. About the Author Dr. Prasad DKV is an Associate Professor in Department of Biochemistry and In-charge Central Research Laboratory, NRI Institute of Medical Sciences at Visakhapatnam, Andhra Pradesh. Dr.Prasad obtained his medical degree from Nagarjuna University, Andhra Pradesh., M.Sc. (Psychology) from Madras University., M.Sc. (Medical Biochemistry) and Ph.D. (Medical Biochemistry) from Dr. N.T.R. University of Health Sciences, Vijayawada, Andhra Pradesh. He has more than 25 years of teaching experience in Biochemistry and also mentored medical graduate and Post-graduate medical biochemistry students to his credit. His research focused on genetics of idiopathic generalized epilepsy (IGE) and its association with oxidative stress and antiepileptic drug therapy. He successfully published his work in national and internationally reputed journals and authored or co-authored few book chapters. He also presented abstracts at various national and international conferences. Dr Prasad tries tolead by example, promoting honesty, integrity, laboratory safety and a healthy work-life balance. In the laboratory, he encourages each student to take ownership of their project, providing scaffolding, advice and troubleshooting when necessary but ultimately letting each person design their own path. He provides opportunities to practice key skills including oral presentations, literature analysis and scientific writing and encourage participation in conferences, internship experiences and travel to work with collaborators around the globe. Dr.Prasad has completed the clinical biochemistry degree MIBCB (Member of Indian Board of Clinical Biochemistry), which is empanelled by Quality Council of India (QCI). He is a member of many international scientific societies and organizations. He is a member secretary for Institutional Ethics Committee, NRI Institute of Medical Sciences, Visakhapatnam. He is a reviewer of several international journals and serves as editorial board member for well reputed international and national journals. Dr. Pinninti Santosh Sushma is a postdoctoral fellow at University of Alabama, Birmingham. Previously, she has completed her Ph.D. from the National Institute of Nutrition. Her work was focused on understanding the role of microRNA in different cancers specifically on the mechanisms of microRNAs targeting tumor suppressor genes and DNA methylation patterns. She has published several research articles in national and international journals of high repute.

Oncology

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Towards New Promising Discoveries for Lung Cancer Patients: A Selection of Papers from the First Joint Meeting on Lung Cancer of the FHU OncoAge … MD Anderson Cancer Center (Houston, TX, USA) (2019) by Paul Hofman PDF

 

Ebook Info

  • Published: 2019
  • Number of pages: 230 pages
  • Format: PDF
  • File Size: 33.41 MB
  • Authors: Paul Hofman

Description

This Special Issue of Cancers (Basel) is mainly dedicated to selecting papers from the talks given during the first Joint Meeting on Lung Cancer (JMLC) between the MD Anderson Cancer Center (Houston, Texas USA) and the Hospital University Federation (HUF) OncoAge (University Côte d’Azur, Nice, France) (Nice, September 2018). The central theme of JMLC is to discuss new advances and exchange ideas regarding lung cancer. Notably, the talks covered different topics on new therapeutic strategies (targeted therapy and immuno-oncology), molecular and cellular biology, biomarkers, and the epidemiology of lung cancer. Special attention was also given to lung cancer in elderly patients. The articles published in this Special Issue covered subjects such as the assessment of new biomarkers and new approaches for the early detection of lung cancer, epidemiological data, and emphasized a place for the newly characterized cellular pathways in lung cancer, which opens room for therapeutic perspectives for lung cancer patients.

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Oncology

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Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care 1st Edition (2021) by Kamil Reza Khondakar PhD. PDF

 

Ebook Info

  • Published: 2021
  • Number of pages: 252 pages
  • Format: PDF
  • File Size: 14.13 MB
  • Authors: Kamil Reza Khondakar PhD.

Description

Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions.Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful.Includes smart sensing materials such as smart electro-active nanomaterials, sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical system, and device integration and interfacing for point-of-care applicationsDescribes each component involved in the development of an efficient cancer diagnostics systemFocuses on fundamental and applied concepts of the technologies, along with the related mechanisms proposed for diagnostics of cancerEnhances fundamental understandings of the concepts and development of nanotechnology based analytical tools and novel techniques for early stage cancer diagnostics and management

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Editorial Reviews: Review Comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, in-vivo and in-vitro From the Back Cover Nanotechnology in Cancer Management: Precise Diagnostics toward Personalized Health Care provides a well-focused and comprehensive overview of technologies involved in early stage cancer diagnostics via the detection of various cancer biomarkers, both in-vitro and in-vivo. The book briefly describes the advancement in cancer biomarker research relating to cancer diagnostics, covering fundamental aspects of various techniques, especially transduction methodologies, such as electrochemical, optical, magnetic, etc. In addition, it describes approaches on how to make options cost-effective, scalable for clinical application, and user-friendly. Advancements in technology related to device miniaturization, performance improvement and point-of-care applications round out discussions.Final sections cover future challenges, the prospects of various techniques, and how the introduction of nanotechnology in cancer management in a personalized manner is useful. About the Author Dr. Kamil Reza Khondakar obtained his doctoral degree from the Centre of Personalised Nanomedicine at Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Australia. He is currently involved in the multiple surface marker profiling of cancer cells and monitor the drug sensitivity effect on the cell surface markers in a Raman (SERS) based microfluidic chip. The aim of his studies is focused on the development of next-generation diagnostics chips for multiple biomarker detection on a single chip to understand the tumor heterogeneity and provide an early detection strategy for cancer management. He received awards and honors due to his contributions to the field of biomedical technology. He was awarded International Postgraduate Research Scholarship (IPRS) from Government of Australia, and University of Queensland Centennial Scholarship (UQCent) from The University of Queensland, Australia. He was invited to give a talk at ‘Biosensor 2018’ conference at Miami, USA.Dr. Ajeet Kaushik is Associate Professor at the NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, USA. He is the recipient of various reputed awards for his service in the area of nano-biotechnology for health care. He has edited seven books, written more than 100 international research peer reviewed publications, and has three patents in the area of nanomedicine and smart biosensors for personalized health care. In the course of his research, Dr. Kaushik has been engaged in the design and development of various electro-active nanostructures for electrochemical biosensor and nanomedicine for health care. His research interests include nanobiotechnology, analytical systems, design and develop nanostructures, nano-carries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nanomedicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring. Read more

Biotechnology

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Integrated Diabetes Care: A Multidisciplinary Approach (2017) by David Simmons PDF

 

Ebook Info

  • Published: 2017
  • Number of pages: 591 pages
  • Format: PDF
  • File Size: 8.3 MB
  • Authors: David Simmons

Description

Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach that could improve care while reducing cost- but has it and can it? Integrated Diabetes Care- A Multidisciplinary Approach collates evidence of worldwide approaches to both horizontal integration (across disciplines) and vertical integration (across organizations) in diabetes care and describe what was done, what worked and what appeared to be the barriers to achieving the goals of the programmes. Evidence is sought from groups who have developed different approaches to integrating diabetes care in different health systems (eg insurance vs tax payer funded, single vs multiple organization, published vs unpublished). A final chapter brings the evidence together for a final discussion about what seems to work and what does not.

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Endocrinology

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International Textbook of Diabetes Mellitus 4th Edition (2015) by R. A. DeFronzo PDF

 

Ebook Info

  • Published: 2015
  • Number of pages: 3404 pages
  • Format: PDF
  • File Size: 28.88 MB
  • Authors: R. A. DeFronzo

Description

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM’s primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease.Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes.This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

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Endocrinology

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Mechanisms of Vascular Defects in Diabetes Mellitus (Advances in Biochemistry in Health and Disease Book 17) 1st Edition (2017) by C.C. Kartha PDF

 

Ebook Info

  • Published: 2017
  • Number of pages: 1194 pages
  • Format: PDF
  • File Size: 13.49 MB
  • Authors: C.C. Kartha

Description

This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality.In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia. In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers.The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section.The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes.Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes.Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglyc

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Cell Biology

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Musculoskeletal Disease Associated with Diabetes Mellitus (2016) by Masaaki Inaba PDF

 

Ebook Info

  • Published: 2016
  • Number of pages: 540 pages
  • Format: PDF
  • File Size: 6.51 MB
  • Authors: Masaaki Inaba

Description

The aim of this book is to review the latest findings on musculoskeletal disease associated with diabetes. It has been increasingly recognized that maintaining skeletal health is an important factor in achieving longevity in healthy subjects. Diabetes has been established as a disease independently associated with sarcopenia and increased risk of bone fracture resulting from osteoporosis; therefore, it is reasonable to maintain that musculoskeletal health is important in preserving good health. As either bone or muscle is intimately involved in the regulation of metabolic status, keeping the musculoskeletal system healthy is important for improving abnormal glucose metabolism toward normal levels and is vital, as well, for maintaining normal activities of daily living. Muscle is a target of insulin for enhancing the entry of glucose; thus it is conceivable that sarcopenia and muscle containing fat streaks causes insulin resistance in diabetic patients. Furthermore, bone is an organ that regulates Ca and Pi levels in serum by releasing or resorbing Ca and Pi to and from bone tissue. It is now known that bone is a definitive endocrine organ for regulating glucose metabolism and Pi metabolism by secreting osteocalcin and FGF-23 from osteocytes/osteoblasts. Readers will learn of the recent findings in this area, and this book will benefit physicians who deal with diabetes, particularly orthopedists and bone specialists, as well as all physical therapists.

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Endocrinology

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Prostate Cancer Imaging: An Engineering and Clinical Perspective 1st Edition (2018) by Ayman El-Baz PDF

 

Ebook Info

  • Published: 2018
  • Number of pages: 392 pages
  • Format: PDF
  • File Size: 33.97 MB
  • Authors: Ayman El-Baz

Description

This book covers novel strategies and state of the art approaches for automated non-invasive systems for early prostate cancer diagnosis. Prostate cancer is the most frequently diagnosed malignancy after skin cancer and the second leading cause of cancer related male deaths in the USA after lung cancer. However, early detection of prostate cancer increases chances of patients’ survival. Generally, The CAD systems analyze the prostate images in three steps: (i) prostate segmentation; (ii) Prostate description or feature extraction; and (iii) classification of the prostate status.Explores all of the latest research and developments in state-of-the art imaging of the prostate from world class experts.Contains a comprehensive overview of 2D/3D Shape Modeling for MRI data.Presents a detailed examination of automated segmentation of the prostate in 3D imaging.Examines Computer-Aided-Diagnosis through automated techniques.There will be extensive references at the end of each chapter to enhance further study.

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Oncology

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Irwin and Rippe’s Intensive Care Medicine: Print + eBook with Multimedia (2023) by Richard S. Irwin PDF

 

Ebook Info

  • Published: 2023
  • Number of pages: 2400 pages
  • Format: PDF
  • File Size: 150.89 MB
  • Authors: Richard S. Irwin

Description

Selected as a Doody’s Core Title for 2023! Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties. Provides easy access to evidence-based critical care practice Offers a practical, clinically oriented approach to intensive care, with detailed descriptions of procedures, incorporating new ultrasound and how-to videos that can easily be accessed in the eBook Key points are identified at the beginning of each chapter and in the margins of the text Key references chosen by the author experts are highlighted at the end of each chapter Available even during network downtime A key educational tool for learning critical care Comprehensive coverage of topics in the field of critical care, including current information provided in 215 chapters authored by well-recognized experts In-depth, comprehensive coverage that allows key skill acquisition Useful resource for board preparation New multiple-choice questions (more than 650!) with annotated answers accompany each chapter in the VST eBook, which also features over 300 videos, mainly diagnostic and therapeutic ultrasound clips. Brings new expertise with senior editor Dr. Walter A. Boyle and online question editor William F. Kelly Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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Anesthesiology

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects (2022) by Sajal Chakraborti PDF

 

Ebook Info

  • Published: 2022
  • Number of pages: 7020 pages
  • Format: PDF
  • File Size: 52.97 MB
  • Authors: Sajal Chakraborti

Description

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.​

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Oncology

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