Advanced systemic mastocytosis – Management and prognosis (2025) Jason Gotlib, MD, MS

Description

This topic discusses the management and prognosis of advanced systemic mastocytosis (advSM), which includes Aggressive Systemic Mastocytosis (ASM), Mast Cell Leukemia (MCL), and SM with an Associated Hematologic/Myeloid Neoplasm (SM-AHN). It covers the clonal nature of mast cell neoplasms, the role of the KIT D816V mutation, and pretreatment evaluation.