Chronic Inflammation and Systemic Manifestations – Outcomes of Acute Inflammation, Causes, and Pathogenesis (2024) Unknown

Description

This text provides objectives and details regarding inflammation, including the four possible outcomes of acute inflammation (resolution, fibrosis, progression to chronic inflammation, or abscess formation). It defines chronic inflammation as a slow evolving process characterized by the absence of polymorphs, presence of macrophages and lymphocytes, continuous tissue injury, angiogenesis, and subsequent scarring (fibrosis). Key causes discussed include persistent infections (e.g., Mycobacterium tuberculosis), immune-mediated diseases (e.g., rheumatoid arthritis), and prolonged exposure to toxic agents (e.g., silica leading to silicosis). It also covers systemic manifestations such as fever and acute phase reactants.