Changes in Liver Disease Etiology Support a Lower Alpha Fetoprotein Threshold for Hepatocellular Carcinoma Screening (2025) Nicole J. Kim

Description

This study evaluates the test characteristics of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening, noting the increasing rates of alcohol-associated liver disease (ALD) and metabolic dysfunction–associated steatotic liver disease (MASLD). The findings suggest that lowering the AFP threshold from ≥20 to ≥10 ng/mL improves test sensitivity while maintaining high test specificity across various liver disease etiologies.