Cancer through the Lens of Evolution and Ecology (2024) Jason A. Somarelli

Description

New cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures. This edited book explores themes including the dynamics of mutation, epigenetics, and gene expression noise as sources of genetic diversity; how scarce resources influence cancer therapy resistance; predator–prey dynamics mirrored in immune-cancer cross-talk; how cancer cells parallel niche construction theory; and how changing fitness landscapes enable cancer growth. It bridges disciplines like cancer biology, ecology, and evolutionary biology, serving as a critical resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles.