Ictal semiology in anterior cingulate epilepsy – A systematic review (2025) Francine Chassoux

Description

Seizures originating from the anterior cingulate cortex (ACC) have distinct clinical features but can be difficult to identify in frontal lobe epilepsy (FLE). This systematic review examines the key semiology of ACC seizures and their anatomical correlations, finding that ACC seizures are predominantly characterized by emotional, autonomic, and striking behavior manifestations contrasting with preserved awareness. Studies included invasive EEG findings and high surgical success rates (80% Engel class I outcome).