Hemophagocytic Lymphohistiocytosis – Review Article (2025) Jan‑Inge Henter

Description

Analysis of Hemophagocytic Lymphohistiocytosis (HLH), a severe and life-threatening syndrome characterized by overwhelming inflammation that often leads to multiorgan failure. The article discusses the classification into primary (genetic) and secondary (acquired) forms, highlighting familial HLH as a successful example of molecular understanding and cure. HLH is presented as an archetype of hyperinflammation relevant to multiple medical specialties including hematology, oncology, pediatrics, and rheumatology.