Motor Neuron Disease – Amyotrophic Lateral Sclerosis Clinical Features and Management (2023) Clinical Review Staff

Description

A concise overview of Amyotrophic Lateral Sclerosis (ALS), a progressive motor neuron degenerative disease. The review covers the definition, unknown etiology, postulated pathogenic causes (free radicals, infection, heavy metals), and characteristic combined manifestations of UMNL (spasticity) and LMNL (wasting, hypotonia). It outlines diagnosis based on clinical findings and EMG, and current management strategies, emphasizing symptomatic and supportive care, non-invasive ventilation, and the role of Riluzole.