Hydrocortisone in very preterm neonates for BPD prevention – Meta-analysis and effect size modifiers (2024) Daniele De Luca

Description

Systematic review and meta-analysis clarifying the role of systemic hydrocortisone (started before the 15th day of life) in preventing bronchopulmonary dysplasia (BPD) and adverse outcomes in very preterm neonates. The study found that hydrocortisone did not reduce BPD, but significantly reduced mortality and necrotising enterocolitis (NEC). The authors suggest that hydrocortisone may be considered on a case-by-case basis to reduce mortality and NEC.