Drug–Drug Interactions (2002) Unknown Author

Description

This book relates pharmacokinetic concepts to Michaelis–Menten kinetics describing in vitro enzyme-catalyzed biotransformation reactions. Focusing primarily on metabolism-based drug–drug interactions resulting from inhibition and induction of drug-metabolizing enzymes (such as cytochromes P450 and UDP glucuronosyltransferases), it covers various in vitro models, kinetics-based in vitro–in vivo correlations, and computer-aided molecular modeling. The subject is presented from preclinical, clinical, toxicological, regulatory, and marketing perspectives.