Hemophagocytic Lymphohistiocytosis (2025) Jan‑Inge Henter

Description

Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening syndrome characterized by overwhelming inflammation that often leads to multiorgan failure and death if not treated promptly and appropriately. The syndrome is classified into primary (genetic, common in children) and secondary (acquired, common in adults) forms. HLH is an archetype of hyperinflammation, requiring recognition in specialties including hematology, oncology, pediatrics, rheumatology, and genetics.