Hepatology

Hepatic encephalopathy is a neuropsychiatric syndrome caused by acute or chronic advanced hepatic insufficiency. Symptoms vary in severity from a mild alteration in mental state to coma but are often reversible with treatment. Causation is thought to be multi-factorial, resulting in brain exposure to ammonia that has bypassed the liver through portosystemic shunting. Diagnosis is based on reported neurological deficits combined with laboratory abnormalities showing severe liver dysfunction. Treatment approaches include providing supportive care (such as preventing aspiration), correcting precipitating factors, and reducing gastrointestinal production of ammonia.

A comprehensive summary defining jaundice and cholestasis, distinguishing between prehepatic, intrahepatic, and posthepatic causes of hyperbilirubinemia. The resource details etiology (including hemolysis, dyserythropoiesis, and impaired hepatic uptake), symptoms (pruritus, dark urine, pale stools), diagnosis via lab markers and ultrasound, and general management strategies for the underlying condition and associated pruritus.

This book addresses the management of hepatocellular carcinoma (HCC) in low and middle-income countries, discussing algorithms for early diagnosis and prioritization of treatment modalities within the context of limited resources and low health care budgets.

Comprehensive, evidence-based recommendations for the management of chronic hepatitis B virus (HBV) infection. The guidelines cover ten thematic sections, including diagnostics, treatment goals, therapeutic options, hepatocellular carcinoma surveillance, management of special populations, HBV reactivation prophylaxis, post-transplant care, and prevention strategies, aiming to equip healthcare providers with tools to optimize HBV care globally.

A comprehensive, evidence-based clinical compendium focusing on liver health and disease management, published as a two-volume set (Volumes 1 and 2).

Analysis of Fatty Liver Disease covering definitions, epidemiology, pathophysiology, diagnosis, and treatment. The material focuses extensively on the new 2023 nomenclature changes, redefining NAFLD as MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) and NASH as MASH.

This book provides a comprehensive review of pharmacotherapy for managing liver cirrhosis and its complications. It covers topics relevant to chronic liver disease progression, treatment, and complications, recognizing the increasing worldwide morbidity and mortality rates associated with conditions like alcohol use, viral hepatitis B and C, and MAFLD.

Autoimmune hepatitis (AIH) is a chronic liver disease of unknown aetiology. The aim of these EASL guidelines is to provide updated guidance on the diagnosis and management of AIH both in adults and children. Updated guidance on the management of patients with variants and specific forms of AIH is also provided, as is detailed guidance on the management of AIH-associated cirrhosis, including surveillance for portal hypertension and hepatocellular carcinoma, as well as liver transplantation in decompensated cirrhosis.

A guide for clinicians focusing on how systemic diseases affect the liver and providing methods for interpreting abnormal liver function tests.

A clinical guide focused on understanding how various systemic diseases manifest in the liver, aiding clinicians in the interpretation and evaluation of abnormal liver function tests.

This book addresses Chronic Hepatitis B infection, recognized as a global health care problem and a significant disease burden worldwide. It covers the potential serious outcomes like liver failure, cirrhosis, and hepatocellular carcinoma, discussing the variable rate of progression and the persistent challenge of managing HBV infection globally despite increasing implementation of vaccines.

A comprehensive guide for clinicians covering the diagnosis, management, and interpretation of abnormal liver tests in the context of various systemic diseases.