Molecular Biology/Oncology

Analysis of the biological process of DNA replication (semi-conservative model), including the Meselson-Stahl experiment. Details the key enzymes involved (Gyrase, Helicase, Primase, DNA Polymerase, DNA Ligase) and the formation of leading and lagging strands (Okazaki Fragments). Also covers the principles, components, and uses of Polymerase Chain Reaction (PCR), including its application in viral diagnostics (rRT-PCR for SARS-CoV-2).

A comprehensive, authoritative textbook detailing the structure, function, and molecular processes within the cell, widely used for teaching fundamental concepts in cell and molecular biology.

This volume details step-by-step, readily-reproducible research protocols and methodologies for epigenome editing, following the established format of the Methods in Molecular Biology series.

A review discussing recent advancements in the production, modification, and cellular delivery of RNA molecules, covering five classes of RNA-based therapeutics: RNA interference-based therapies, antisense oligonucleotides, small activating RNA therapies, circular RNA therapies, and messenger RNA-based therapeutics. It also examines regulatory approvals, clinical trials, and challenges in the field.

A thematic volume in the Advances in Experimental Medicine and Biology series, providing a platform for scientific contributions in biomedicine and the life sciences, focusing on contemporary research regarding Cancer Stem Cell Markers and Related Network Pathways.

A comprehensive encyclopedia aiming to supply the reader with concise information on molecular pathophysiology. It is intended as a valuable companion for both basic scientists exploring clinical hallmarks of diseases and clinicians searching for insight into the molecular pathophysiology of their patients.

This book, part of the Methods in Molecular Biology series, provides detailed methods and protocols for applying computational and data analysis techniques (bioinformatics) to the study of microRNA research.

This volume, part of the RNA Technologies series, provides critical and comprehensive discussions of the most significant areas of RNA research, including RNA interference, RNA biosynthesis and metabolism, microRNAs, transcriptome analysis, and aptamers. It explores recurring themes such as RNA-protein interactions, genetic network analysis, and the promise of small RNAs as cancer diagnostics and therapeutics, emphasizing the potential of RNA-based approaches in molecular biology, cell biology, biomedical research, and medicine, including efficacy against viruses like SARS-CoV-2.

A review summarizing key strategies and novel technologies developed to decode genome-wide RNA structures (the RNA structurome) across various species. It discusses the application of these technologies to dissect the structural landscape of SARS-CoV-2 RNA and the functionalities of RNA structures in regulatory layers including processing, transport, localization, and mRNA translation.

A comprehensive reference covering the methods, research, and evolving best practices in the field of molecular diagnostics. It emphasizes staying current with new research and clinical experience in this rapidly changing medical field.

This volume provides readily-reproducible, step-by-step research protocols and methodologies specific to medulloblastoma. Each protocol includes an introductory overview, a list of materials and reagents needed, a detailed procedure, and a helpful notes section offering tips and troubleshooting advice, following the standard set by the Methods in Molecular Biology series.

An accessible guide explaining the complex principles of molecular biology using the visual and narrative style of Japanese manga comics.