Molecular Pathology

This book examines the latest developments in molecular pathology and the use of biomarkers in the diagnosis and research of primary unknown carcinomas (Carcinoma of Unknown Primary, CUP). It emphasizes the growing importance of molecular pathology methods in clinical practice.

A foundational text detailing the principles and practice of molecular pathology, covering methods from cytogenetics and DNA sequencing to advanced Next-generation Sequencing (NGS) and bioinformatics. The book provides extensive coverage of applications in solid organ cancers, blood cancers (lymphoma, leukemia), and various rare, inherited, and metabolic diseases across multiple organ systems.

This textbook, the second edition, explores the molecular mechanisms underlying human diseases. Key topics include molecular mechanisms of cell death, acute and chronic inflammation, host-pathogen interactions, neoplasia, and basic human molecular genetics. It also covers advanced concepts related to the human genome in the post-genomic era and the utilization of transcriptome analysis (microarrays and RNA sequencing) in understanding, diagnosing, and treating human disease.