Designing Clinical Research (2013) by Dr. Stephen B Hulley MD MPH PDF

 

Ebook Info

  • Published: 2013
  • Number of pages: 378 pages
  • Format: PDF
  • File Size: 4.23 MB
  • Authors: Dr. Stephen B Hulley MD MPH

Description

Designing Clinical Research has been extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing.New to this edition:Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirementsColor format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary

Reviews

Reviews from Amazon users which were colected at the time this book was published on the website:

⭐Clinical Trials have evolved over the past few decades in multiple dimensions. There are legal, regulatory, statistical, procedural, and clinical dimensions which tend to structure them in ways which were not prevalent to anyone who entered medicine decades earlier. The book by Hulley et al, Designing Clinical Research, is a wonderful overview of most of these dimensions. It brings the reader up to date with many of the key factors which have become part of Trials and give an excellent amount of depth so that the book stands on its own.The book is divided into three major sections; (i) Basics including sampling, trial hypotheses testing and statistical analyses as well and general trial types. (ii) Designs which examines the various types of trials from randomized case control, cross-sectional, and other such classic trial methodologies, (iii) Implementation, including the ethical issues and data management.The Basics provides a reasonable overview of the randomization, sizing, and the establishment of the statistical plan for a Trial. The approach is classic with the null hypothesis approach and the metrics necessary for properly sizing a successful Trial. The presentation is in a summary nature and the reader is either expected to be familiar with the development of the mathematics or just to use the Tabular approaches as presented. There are excellent discussions on various approaches such as continuous versus dichotomous and the material is useful even for those well experienced in the area.The Designing sections go over the details associated with various Trial approaches and discuss the implementation, and the advantages and disadvantages. Again, even for someone already familiar with the material the authors provide added insight well worth the reading. Again when discussing such elements as likelihood designs and Receiver Operating Characteristics the material is of a summary nature, adequate for both understanding and application but not of any material depth. Yet that was never the objective of the book.Finally in implementation the authors present an excellent discussion of the Ethical Issues that are frequently found in many Trials. There are other elements here as well but the Ethical discussions have become more prevalent to current day Trials.The challenge that this and other works on Trials will be facing are the Trial involving genome based approaches. For example in MDS and the use of demethylating therapeutics such as azacytidine and others one may ask the ethical question; if this is demethylating and methylation is both the cause while also being a control in other cells, how long should one wait to see long term effects? In cases such as the BRAF inhibitors in melanoma, what import is the extension of life if the costs are so great? Also how aggressively should one approach multiple drug therapies? Finally, as we see more genetically specific drugs on a patient by patient basis, can Trials like those discussed herein still be considered a gold standard and if not what then would take their place. Therapeutics targeted at a specific genome type will be difficult to analyze as we have with large Trials discussed in the book.Overall the book is a superb overview of Trials and is worth a read by finishing Med Students, Resident, and even those experienced in Trials. It is well written, logically laid out, considers almost all the key questions, and presents information adequate for most.

⭐This is a concise and precise book that gives a very good practical description to conduct various types of studies. Though the title is clinical research I believe it is also a good resource for epidemiologic research. After having read large books on how to conduct research this book is a relief. It does not dwell on extraneous stuff and focuses only the essentials and still manages to captivate the reader.

⭐A very current and thorough treatment of clinical research design by recognized experts in the field. A handy compendium with immediate utility when engaged in the ethics review of clinical research.

⭐Great for MDs or PhDs wanting to refresh their knowledge on how to design the strongest research methodology they can. Clearly written book discussing different study designs and their pros and cause when trying to establish a causal association between an exposure and a disease event (or intervention and reduced disease event). This book focuses on clinical research, but is often used in public health courses that deal with general community research as well.The fact that it’s used often as a textbook is reflected in its very high price point.

⭐Absolutely essential for anyone working in clinical research. One of the best books I’ve ever had, cery well written.

⭐I read this book during my clinical research studies. I continue reading it after graduation. I always look forward to the re-introduction of the material. At the same time, I learn something new from the book. I would highly recommend it to clinical research students. It is an excellent required and recommended textbook.

⭐This book is excellent in the way it approaches the research subject in the medical field. If you want to learn about clinical research, this is a most.

⭐I’m using this for my research methods course while I’m in my clinical rotation. It’s definitely helped as the topics in this book have been quite relevant to my project and application in general.

⭐Easy to understand for someone who does not have background in clinical research

⭐Fantastic layout – easy to read and understand – it is a fantastic educational tool

⭐Excelente libro..

⭐This books is essential to understand how clinical trials are designed.The book is a part of the course/workshop offered elsewhere.It is well organized, just enough details and breadth of coverage.The edition is recent and alongwith the hardcopy the book canalso be accessed on iPhone(inkling app) and web using the web content.So buying a new book with unscratched code is worth the money spent.

⭐It is very easy to understand.It is worthy

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Development of the Ocular Lens 1st Edition (2004) by Frank J. Lovicu PDF

 

Ebook Info

  • Published: 2004
  • Number of pages: 414 pages
  • Format: PDF
  • File Size: 34.9 MB
  • Authors: Frank J. Lovicu

Description

This comprehensive study of the developmental biology of the ocular lens will serve as a reference for graduate students and research scientists in the visual sciences and developmental biology, as well as for ophthalmologists. Clarification of the mechanisms that govern normal lens development is fundamental to our understanding of lens disorders. The lens has also become a model for studying more complex organ systems. Leading experts in lens development and structure discuss lens induction, evolution, cell cycle regulation, morphology, fiber cell differentiation, and regeneration.

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Development of the Visual System (Proceedings of the Retina Research Foundation Symposia, Vol. 3) (1991) by Dominic Man-Kit Lam PDF

 

Ebook Info

  • Published: 1991
  • Number of pages: 312 pages
  • Format: PDF
  • File Size: 6.19 MB
  • Authors: Dominic Man-Kit Lam

Description

Expands the classical description of the development of visual systems based on neural systems to the cellular and molecular level, in 16 studies first presented to the Retina Research Foundation symposium in Woodlands, Texas, in May 1990. Reporting on research ranging from fish and frogs to the abnormal visual experience on the primary visual cortex of the cat, addresses four specific aspects: cell lineage and fate, specificity and targeting of axions, the specification of the visual cortex, and correlates of the critical period. Annotation copyright Book News, Inc. Portland, Or.

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Immuno-Ophthalmology (Developments in Ophthalmology) 1st Edition (1999) by U. Pleyer PDF

 

Ebook Info

  • Published: 1999
  • Number of pages: 252 pages
  • Format: PDF
  • File Size: 3.47 MB
  • Authors: U. Pleyer

Description

Although considerable light has been shed on the mechanisms of ocular immunity in the last two decades of the 20th century, a complete understanding still eludes our grasp. This volume brings findings in immunological research and the resulting new therapy methods to the ophthalmologist in practice. The scope of the topics goes from general principles of immuno-ophthalmology to more specific ones such as immunology of corneal transplantation or immune regulation of uveoretinal inflammation.

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Diabetes and the Eye: Latest Concepts and Practices (Diabetes: Current and Future Developments) (2021) by Douglas R. Lazzaro PDF

 

Ebook Info

  • Published: 2021
  • Number of pages: 247 pages
  • Format: PDF
  • File Size: 3.48 MB
  • Authors: Douglas R. Lazzaro

Description

Diabetes and the Eye familiarize the readers with the relationship between diabetes mellitus and the visual system. It presents a discussion about the diabetes epidemic and the many ways the disease can cause vision loss, with several types of vision disorders covered in separate chapters. Information about new frontiers in the treatment of ophthalmic disorders is also presented to reflect the advances being made in the clinic.Key features:- presents detailed coverage of vision loss in diabetes in 12 organized and easy to read chapters- includes a discussion on the diabetes epidemic- covers a wide range of vision disorders, of different parts of the eye- includes information on current practices in eye care and management for diabetic patients- includes information about relevant diagnostic toolsThis book serves as a useful handbook for medical students, residents in ophthalmology, community and academic ophthalmologists, as well as members of the internal medicine and family practice communities.

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Digital Eye Care and Teleophthalmology: A Practical Guide to Applications 2023rd Edition (2023) by Kanagasingam Yogesan PDF

 

Ebook Info

  • Published: 2023
  • Number of pages: 546 pages
  • Format: PDF
  • File Size: 0.71 MB
  • Authors: Kanagasingam Yogesan

Description

This book describes digital ophthalmology and telemedicine applications for both front of the eye and retina. It includes technical issues, digital imaging, what clinical parameters to use, which technologies are suitable, and collective experiences of practitioners in different parts of the world practicing a wide range of digital eye care delivery. The main purpose of this book is to provide adequate information to clinicians and other health professionals who are involved in eye care delivery to assess how digital health in ophthalmology might be applied to their working practice, how digital screenings are performed, and to learn about virtual image reading. Many of the chapters are also helpful to health service managers, imaging specialists, and information technology staff.Digital Eye Care and Teleophthalmology: A Practical Guide to Applications examines digital eye care to provide state of art ophthalmic services. It is an essential resource for professionals involved in eye care seeking to develop or improve their digital applications in daily practice.

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Diabetic Eye Disease: An easy to understand guide to keeping your vision for people with diabetes (2018) by David Khorram MD PDF

 

Ebook Info

  • Published: 2018
  • Number of pages: 202 pages
  • Format: PDF
  • File Size: 1.86 MB
  • Authors: David Khorram MD

Description

Millions of people lose vision from diabetes. Make sure you’re not one of them. In this revised and updated second edition, award-winning ophthalmologist, writer and educator, Dr. David Khorram serves as your guide, giving you the knowledge you need to keep your vision for a lifetime.This easy to understand guide begins with a description of how the eye works and how diabetes causes damage, not just in the eye but throughout the body. Dr. Khorram then discusses the stages of diabetic retinopathy, as well as other diabetic related problems such as cataracts, fluctuating vision and double vision. Dr. Khorram goes on to explain the types of doctors that provide diabetic eye care, the details of the eye exam, and an overview of special eye tests that you may need to evaluate diabetic eye disease. A separate section discussed treatment of diabetic eye disease, including laser treatment, surgery, and the use of revolutionary drugs such as Avastin which can stabilize and even reverse vision loss. Finally, Dr. Khorram touches on issues related to control of diabetes and other health problems that can play a major role in helping you prevent blindness.”An outstanding book for people with diabetes and their families.” ~John T. Thompson, MD, President, American Society of Retina Specialists “The depth and clarity of Dr. Khorram’s book are amazing and it is a godsend to people with diabetes.”~Frank Harritt, Founder and CEO of Diabetes Self-Defense, LLC “Having lived with diabetes for over 30 years and treated patients with diabetes for more than 20, I can say that Dr. Khorram does an outstanding job explaining the how’s and why’s of diabetic eye care in a sensible and understandable way. This is one book that I plan to read for a lifetime!”~Gary Scheiner, MS, CDE, author of Think Like a Pancreas: A practical guide to managing diabetes with insulin “If knowledge leads to action, you are well on your way to a lifetime of healthy vision. This book answers all your questions…”~Jill Weisenberger, MS, RD, CDE, author of Diabetes Weight Loss – Week by Week “I thoroughly enjoyed the book. I was blown away by all the details provided and with photos to illustrate the information. The book is a complete guide on the progression of the effects of diabetes on the eyes, and covers the latest developments of treatment alternatives. A good reference book to understand what your doctor is trying to convey. Very well written in a casual and personal style. P.S. Armed with information from Dr. Khorram’s book I was able to convince my husband to drastically modify his diet to control his diabetes. We just saw our physician. Not only has my husband lost 20 pounds in three months, but his AC1 is 5.6! His cholesterol is also normal and his medications have been cut way back. Now he has the motivation to monitor himself and we are gradually adding healthy carbs.”~smithwic, Amazon review of the first edition

Reviews

Reviews from Amazon users which were colected at the time this book was published on the website:

⭐Khorram and Liu do a fantastic job of making everything about diabetic eye disease easy to understand for the patient and anyone else interested in the subject. The book is divided into three sections: 1) Diabetes and the eye, 2) The Eye Exam, 3) Treatment, and 4) Controlling Diabetes and Getting Healthy. Throughout the book, they focus on the information that is relevant to the patient, giving background on the physiology of disease and structure of the eye with just the right amount of depth and detail. Khorram points out that people have a tendency not to go to exams unless they are “feeling sick” and explains how diabetic eye disease can progress even when no symptoms are present, and really helps you understand the biological basis behind how powerful preventative care is. The eye is such a critical part of how we live daily that I really think the advice he provides is critical for anyone with diabetes who might be in danger of developing diabetic eye disease. In addition, Khorram and Liu thoroughly go through every step of the eye exam and treatment in a compassionate and comforting manner, without dumbing down anything. A lot of anxiety comes from the unknown, but the thorough and understandable explanations in this book take much of that away and make the entire process non-intimidating.I’d full-heartedly recommend this book to anyone with diabetes or if you know someone with diabetes. Regardless of your scientific background, you will be able to understand the disease better, know your treatment options, and feel better about going through the journey. Thank you Khorran and Liu for this wonderful contribution to the field.

⭐This was an incredibly clear and helpful book. As someone with minimal prior knowledge about the eye, I found this book to be very approachable, and I feel more knowledgeable about the eye now. The clear language made it very easy to follow, and the authors truly did a magnificent job of covering the most important information. As a student interested in health and medicine, I especially appreciated the balance of scientific terms and every-day language. Finally, the breakdown of the book contributed to its approachability. The first part, “Diabetes and the Eye,” gives a thorough background about the eye and essentially shows the reader why they should care about how diabetes affects vision. The second part, “The Eye Exam,” was an enjoyable section to read, as I did not know there were more parts to an eye exam other than the classic Snellen eye chart. The third part, “Treatment,” contains invaluable information that I do not doubt a patient with diabetic eye disease would use to help guide their course of treatment. Finally, the last section, “Controlling Diabetes and Getting Healthy,” gives a concise overview of steps patients can take to make an even greater (positive) impact on their visual health. Overall, I highly recommend this book to anyone with diabetic eye diseases or people who are simply interested in learning more about the eye–it is concise yet thorough, and I feel much more knowledgeable having read this book.

⭐Too often, there is a disconnect between what doctors and patients know. This leads to negative outcomes in medicine whereby patients feel unempowered and unable to take control of their own health, left thinking they don’t know enough to take care of themselves. The result is not only a loss of confidence and a feeling that one cannot take care of themselves, but worse health outcomes as patients think they can’t make changes to help themselves – essentially responsibility for health and medical care is displaced to doctors as patients doubt themselves. There is great power in education. Patients will feel that they can indeed take care of themselves, that they do know what’s going on in their bodies, and with this knowledge, they will feel responsible and empowered to live healthier lives.This book is what medicine needs – an easy to understand guide not only to diabetic eye disease but the eye’s anatomy in general. It is extremely easy to read and is accessible to patients without formal medical or scientific backgrounds. It can teach people about how diabetes affects their vision, but also how the eye is composed so that people may take proactive steps to ensure optimum eye health.I wholeheartedly recommend this book for those facing uncertanties with their vision – especially those who don’t know what’s going on and want to develop their knowledge base and regain their autonomy.

⭐I like this book because I found it’s easy to read and helpful. I feel this book is helpful for individuals with diabetes and their families. It gives a general but important guideline for individuals with diabetes to protect their vision. This book provides information about diabetes and the eye; the importance of eye examination and follow-up care; and what treatments can be helpful. I believe people may save and keep their vision if they read this book.

⭐I know little about eyes and diabetic eye disease, but I found this book very easy to read and follow (as its subtitle describes “an easy to understand guide”). It walks readers step by step, covering basics of diabetes and the eye, how to do eye exam and how to receive treatment.

⭐The book can help patients gain the knowledge they needed. The author emphasizes the importance of the eye exam. Patients should never wait for symptoms to appear before coming to see a doctor. The author wrote the book in the same every-day language, so it was very easy to understand and felt warm.

⭐This books provides readers easy-to-ready angles to understand the diabetic eye disease. It is fun to read and easy to understand.

⭐This book provides a thorough information about diabetic eye disease, which is easy to understand. From basic eye anatomy to exam methods, it will be a good guide for people who are suffering and who want to help.

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Diabetic Macular Edema (2022) by Sandeep Saxena PDF

 

Ebook Info

  • Published: 2022
  • Number of pages: 227 pages
  • Format: PDF
  • File Size: 28.42 MB
  • Authors: Sandeep Saxena

Description

The book focuses on diabetic macular edema and provides comprehensive practical knowledge on the subject. This timely book summarizes all the aspects of diabetic macular edema. The book is edited by leading authorities of vitreoretinal diseases having expertise in diabetic macular edema. It comprises over dozen chapters, authored by a subject authority in the world. Chapters provide diagnostic, medical and surgical approach. The book is clinically relevant, covers application of the latest clinical trials as well as application of novel imaging technologies. It includes uniquely structured chapters for easy learning.
The book is beneficial to ophthalmic resident doctors, retina fellows and practicing retina specialists throughout the world.

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Diabetic Retinopathy: Current Pharmacologic Treatment and Emerging Strategies (2017) by Michael W. Stewart PDF

 

Ebook Info

  • Published: 2017
  • Number of pages: 281 pages
  • Format: PDF
  • File Size: 6.76 MB
  • Authors: Michael W. Stewart

Description

A well-illustrated and comprehensive analysis of the treatment of diabetic retinopathy, this book covers current treatment options and guidelines, whilst also providing a detailed discussion of emerging therapeutic targets. Existing therapeutic options are covered in depth, with a major focus on anti-vascular endothelial growth factor drugs and sustained release corticosteroids, including a review of trial results supporting current treatment guidelines. The use of agents off-label is also discussed. Controversial topics are discussed in detail with an emphasis on helping the reader make informed decisions, particularly when treating patients for which several treatment approaches may be appropriate because trial data does not clearly define the best option.Emerging therapeutic areas are evaluated, as work continues to identify agents that produce superior morphologic responses and visual acuity gains by targeting other molecules that contribute to diabetic retinopathy. Promising new drugs, targets and delivery systems are identified, and their development analysed.

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Diabetic Retinopathy 1st Edition (2015) by M.D. Lumbroso, Bruno PDF

 

Ebook Info

  • Published: 2015
  • Number of pages: 100 pages
  • Format: PDF
  • File Size: 11.39 MB
  • Authors: M.D. Lumbroso, Bruno

Description

Diabetic Retinopathy is a concise guide to the condition caused by complications of diabetes, which can eventually lead to blindness. The book is edited by a team of experts from the Italian Macular Centre in Rome, led by Prof Bruno Lumbroso.Divided into ten chapters, the book begins with basic information on diabetes and diabetic retinopathy. Further chapters demonstrate how to read and interpret different forms of imaging, including fluorescein angiography, cross-section OCT, and ‘en-face’ OCT. Information on the use of the most recent OCT angiography imaging techniques brings this book fully up to date.73 full colour images and illustrations enhance the text, which highlights the importance of clinical imaging in everyday treatment of diabetic retinopathy. Diabetic Retinopathy is an essential guide to imaging and treatment for ophthalmologists and optometrists.Key Points Concise guide to diabetic retinopathy, including imaging modalities and treatment Up to date information on new imaging techniques Full colour images and illustrations throughout Expert editorial team from Italian Macular Centre, Rome

Reviews

Reviews from Amazon users which were colected at the time this book was published on the website:

⭐Great book

⭐Schematic presented the lessions and pathology changes, easy to understand the topography. Usefull tool.

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