Metabolic Dysfunction–Associated Steatotic Liver Disease – Review Article (2025) Giovanni Targher, M.D.

Description

This review discusses the global clinical burden and consequences of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a multisystem disease. It details the natural history, pathophysiology, risk stratification, and case finding of the disease, focusing on new and promising metabolism-based pharmacotherapies targeting the liver and coexisting cardiovascular–kidney–metabolic conditions.